Question Consider the following tablet formulation for a new drug Y (hydrophobic drug) per tablet which was manufactured by dry granulation: Drug Y ….

Question Answered step-by-step Question Consider the following tablet formulation for a new drug Y (hydrophobic drug) per tablet which was manufactured by dry granulation:Drug Y …………………………………………….. 250 mgMicrocrystalline cellulose ………………….. 90 mgPVP ……………………………………………………. 30 mgSodium starch glycolate …………………….. 18 mgSodium lauryl sulfate ……………………………. 6 mgLactose …………………………………………….. 106 mgDescribe TWO possible reasons for the need to granulate the drug-excipients mixtures as dry rather than wet granules. Describe TWO possible conditions for compressing the drug-excipients mixtures directly without granulation. During the initial run, samples from the tablets were tested for hardness and disintegration and found to be too hard and took more than 30 minutes to disintegrate completely. Suggest two formulation strategies to overcome this problem. During the initial run, samples from the tablets were tested visually and some tablets showed sticking and picking. Describe each term, the causes and how to avoid these defects. Explain why tablets have slow onset of action compared to powdered dosage form by explaining the different stages for the drug in immediate release tablets before it is available at the site of action. We are to design the drug in this tablet for extended release and tablets need to be film coated. Explaining your selection, outline TWO examples of suitable polymers and their relative properties for an efficient coating. You will need to refer to the handbook of pharmaceutical excipients for the actual properties of the selected polymers. Explain what will happen to the drug disintegration and dissolution rate if sodium lauryl sulfate (sulphate) was replaced by magnesium stearate. Health Science Science Nursing HEALTH PHAR1017 Share QuestionEmailCopy link Comments (0)