Identify a specific genetic disorder (such as sickle cell anemia,…

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Question Answered step-by-step Identify a specific genetic disorder (such as sickle cell anemia,… Identify a specific genetic disorder (such as sickle cell anemia, cystic fibrosis, cancer based on oncogenic Ras, etc.) and describe a gene therapy approach using one of the methods we covered in class: RNA interference, CRISPR, aptamers. In your answer, be sure to address each of the following:The nature of the defect, and the disease it causes.The specific method you propose to fix the defect, including a brief description of how it works.The specific method by which the molecular fix will be delivered (virus, etc.).A brief description of specific challenges in applying this fix. Science Biology BIO 186 Share QuestionEmailCopy link Comments (0)

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Question Answered step-by-step Star Point 4: (Implementation)Describe the process for gaining permission to plan and begin a trial.  Is there a specific group, committee, or nurse leader involved?Typically, staff of the hospital's Research and Development Department organize and implement clinical trials. To ensure that the study is viable and fits the requirements of the target population, relevant stakeholders (e.g., nurses, physicians, patients, etc.) should be consulted early in the process. Individuals who are invested in the trial's success and will play a role in its implementation are considered key stakeholders (e.g., nurses, physicians, patients, etc.). It is possible to guarantee that the study is viable and satisfies the requirements of the target group by talking with these persons early on. Stakeholders can give useful feedback on the trial design and assist in the identification of any possible trial implementation difficulties. Describe the plan for educating the staff about the change process trial and how they will be impacted or asked to participate.Any change process experiment should include staff education. The Research and Development Department of the hospital would be in charge of creating an educational plan for the personnel. This strategy would contain details about the experiment, how it would affect workers, and what they should expect. Outline the implementation timeline for the change process (start time/end time, what steps are to occur along the timeline).The first step in acquiring clearance to organize and launch a study would be to contact the hospital's Research and Development Department. This department is in charge of all research initiatives, including clinical trials, that take place within the hospital. The study team would collaborate with hospital personnel to put the intervention in place, which would most likely entail training on the new intervention, how it would be administered, and how employees will be affected or requested to participate. The length of time it takes to completely execute the intervention may vary depending on the trial's details, but it will often take several months. List the measurable outcomes based on the PICOT.  How will these be measured?Multicomponent pressure ulcer prevention techniques are likely to reduce the risk of pressure ulcers and assist their healing in 60-80-year-old people in acute and long-term care hospitals. This will be determined by comparing medical records to see if there is a difference in the number of pressure ulcers developed in the intervention group vs the control group, as well as the time it takes for those pressure ulcers to heal. What forms, if any, might be used for recording purposes during the pilot change process. Describe.Checklists, questionnaires, and data gathering tools are examples of forms used for documenting reasons throughout a pilot modification process. This will vary depending on the study. What resources are available to staff (include yourself) during the change pilot?Because novel interventions might overwhelm employees, it's critical to give education and support during the pilot. The research team may tell employees about the new intervention, assist them in understanding how it will be implemented, and give support during the pilot. Will there be meetings of certain stakeholders throughout the trial?  If so, who and when will they meet?Various stakeholders are expected to meet at various times during the trial. Staff, researchers, and patients/families are examples of stakeholders. Meetings might be held on a regular basis or just when necessary. Every three months, the stakeholders will meet to review the trial's progress and discuss any concerns that have developed. *****Questions******  This trial is for Pressure Ulcer Prevention  1. How will you report the outcomes of the trial? 2. What would be the next steps for the use of the change process information? Health Science Science Nursing NR 451 Share QuestionEmailCopy link Comments (0)
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Describe the benefits and dangers associated with genetic screening.
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