The following figure illustrates how HER2 transcription is…

Question Answered step-by-step The following figure illustrates how HER2 transcription is… The following figure illustrates how HER2 transcription is regulated in different tissues. The 3 diagrams show the region of the HER2 gene and the activator proteins present in the breast, ovarian and liver tissues. Activator molecules with specific shadowing can bind to enhancers (enhancers) with the same shadowing. The HER2 protein is a receptor tyrosine kinase (RTK) involved in cell growth. The HER2 gene is therefore a proto-oncogene   1-Chantale inherits a mutation in the enhancer 2 gene. In the DNA of which tissue(s) would you expect to find the enhancer 2 gene mutation?a-Ovariesb-Boobsc-Breasts and ovariesd-Livere-All fabrics 2-As mentioned earlier, HER2, a receptor tyrosine kinase from the same family as EGFR, and it is potentially oncogenic. If HER2 becomes oncogenic, at what stage of the cell cycle will its “oncogenicity” begin to have an effect on cell cycle advancement?a-Mb-G2c-Sd-G1 3-We discover in Julie a homozygous mutation which destroys the sequence of the breast enhancer of the HER2 gene. Which of the following scenarios is most likely?a-Activator 1 can no longer be expressed in breast cells.b-Activator 1 will no longer be able to bind to its enhancer in order to increase the expression of HER2c-If the HER2 gene is transformed into an oncogene, the risk of breast cancer will increase for Julie.d-There is less risk of HER2 becoming an oncogene. 4-In which tissue(s) is the HER2 gene expressed?a-Breasts and ovariesb-Boobsc-Ovariesd-Livere-All fabrics 5-A mutation in the enhancer 3 gene allows expression of enhancer 3 in the ovaries. Which of the following statements is the most likely?a-HER2 gene expression will decrease in the liver.b-The presence of activator 3 in the ovaries will compete with activator 2 to bind to its enhancer.c-HER2 gene expression will increase in the ovaries.d-The presence of activator 3 in the ovaries will not affect the expression of HER2 in this tissue. 6-If HER2 becomes oncogenic and we wanted to find a way to decrease its oncogenic effect, which of the following strategies would be the best choice?a-Stimulate the expression of a tumor suppressor.b-Use a HER2 inhibitor antibody.c-“Repair” cancer cells by adding a normal copy of the HER2 gene.d-Use a MAPK signaling pathway inhibitor.e-Stimulate the acetylation of histones located at the level of the HER2 promoter. 7-Which of the following mutations will not affect HER2 gene expression in the ovaries?a-A mutation in the DNA-binding domain of activator 2.b-A mutation in the coding sequence of the HER2 gene.c-A mutation in the signal peptide of activator 2.d-A mutation in the promoter of the HER2 gene. Biology Science Microbiology BIOCHEMIST 12 Share QuestionEmailCopy link Comments (0)