1. Explain why some cancer cells are resistant to chemotherapy? 2….
Question Answered step-by-step 1. Explain why some cancer cells are resistant to chemotherapy? 2…. 1. Explain why some cancer cells are resistant to chemotherapy?2. The WRN gene codes for the Werner protein, which is found in the nucleus where it performs various functions. A mutation in this gene results in a shorter protein length which is unable to translocate to the nucleus, in a condition known as Werner syndrome. Give possible reasons why nuclear transportation for the mutated protein is impaired?3. Your friend is going for an organ transplant procedure. He is worried he has to take an anti-transplant rejection medication. As a friend cellular biologist reasons why this medication is necessary?4. Giving an example of a transporter and with reference to transepithelial transport, explain why it is necessary to use both salt and sugar in oral rehydration therapy but not sugar or salt alone?5. (a) What is nephrogenic diabetes insipidus? (b) Give reasons why SGLT2 inhibitors are beneficial as add on treatment in type 2 diabetes?6. Outline the processes that lead to the activation of a second messenger in GPCR signaling. Explain concisely how proteostasis dysfunction can lead to cellular aging?7. Amiodarone is ß-adrenergic inhibitor which is also used to block the activity of delayed rectifier channels during an action potential. It is administered to patients suffering from anythmia (irregular heart beat). Give reasons why the action of this drug is necessary for the treatment of arrythmia.8. Organophosphates, which may be present in some pesticides, are potent inhibitors of acetylcholinesterase. What would be the implication of organophosphate exposure on skeletal muscle contraction?9. Not all senescent cells are aged cells. With your knowledge in cell physiology,10. What are the two major types of ion channels found in neurons and how are they activated?11. Why is it that siblings have DNA variations and why is it that siblings do not have the same DNA? Biology Science Physiology APHY 101 Share QuestionEmailCopy link Comments (0)
