Glycogen synthase (GS) catalyzes the formation of a(14) glycosidic…

Question Glycogen synthase (GS) catalyzes the formation of a(14) glycosidic… Glycogen synthase (GS) catalyzes the formation of a(1à4) glycosidic bonds in glycogen by catalyzing the transfer of UDP-glucose to a glycogen particle where UDP is a byproduct. It is regulated by allosteric modulators and phosphorylation coupled to hormones. Assume GS is a K-system enzyme. Given this information, answer the following questions. a) Do you expect the binding of the substrate UDP-glucose to favor the R or T state of the enzyme or neither? b) Draw a plot of the rate of GS versus UDP-glucose. Label the axes, define the half-maximal substrate binding (K0.5) point, and mark the curve with the label UDP-glucose. c) GSK-3 from Question 3 above phosphorylates GS, thus inhibiting the enzyme. When GS is phosphorylated, do you expect the R or T state of the enzyme or neither to be favored? d) On the same plot that you drew for part (b) now add a second curve indicating the effect of phosphorylation. Define the half-maximal substrate binding (K0.5) point and mark the curve with the label GS-P. Biology Science Biochemistry BIOL 3361 Share QuestionEmailCopy link Comments (0)